Back to Search
Start Over
Rat brown adipose tissue thermogenic features are altered during mid-pregnancy.
Rat brown adipose tissue thermogenic features are altered during mid-pregnancy.
- Source :
-
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2005; Vol. 15 (5), pp. 203-10. - Publication Year :
- 2005
-
Abstract
- Brown adipose tissue (BAT) thermogenesis is inhibited during late-pregnancy and lactation in the rat. However, scarce information concerning BAT functionality during mid-pregnancy is available. The aim of this work was to investigate uncoupling proteins and leptin expression during placentation in rat BAT as well as other key parameters in the thermogenic function of the tissue. BAT mitochondrial content was found to be reduced 50% in 11 and 13 day pregnant rats as compared to nonpregnant controls, although uncoupling protein 1 (UCP1) content was not modified. Furthermore, UCP3 mRNA levels were found to be highly increased during this period. beta3-adrenergic receptor (beta3-AR) decreased expression resulted in a higher alpha2/beta3 ratio. Finally, leptin mRNA levels in BAT were found to be 3-fold up-regulated in pregnant animals. In conclusion, we show the existence of profound changes in thermogenic features in BAT during gestational days 11 and 13, pointing to the importance of this tissue during mid-pregnancy.<br /> (Copyright 2005 S. Karger AG, Basel)
- Subjects :
- Animals
Carrier Proteins genetics
Female
Gene Expression Regulation
Ion Channels
Leptin genetics
Membrane Proteins genetics
Mitochondria metabolism
Mitochondrial Proteins
Placentation genetics
Placentation physiology
RNA, Messenger analysis
RNA, Messenger metabolism
Rats
Rats, Wistar
Receptors, Adrenergic, beta-3 genetics
Receptors, Adrenergic, beta-3 metabolism
Thermogenesis genetics
Uncoupling Protein 1
Uncoupling Protein 3
Adipose Tissue, Brown metabolism
Carrier Proteins metabolism
Leptin metabolism
Membrane Proteins metabolism
Pregnancy metabolism
Thermogenesis physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1015-8987
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 15956783
- Full Text :
- https://doi.org/10.1159/000086407