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Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients.
- Source :
-
Blood [Blood] 2005 Oct 01; Vol. 106 (7), pp. 2491-7. Date of Electronic Publication: 2005 Jun 09. - Publication Year :
- 2005
-
Abstract
- In the new World Health Organization/European Organization for Research and Treatment of Cancer (WHO/EORTC) classification of cutaneous lymphomas, large B-cell lymphomas (LBCLs) are divided into 3 groups: LBCL, leg-type (LBCLLT); follicle center lymphoma, diffuse type (FCLDT); and LBCL, others (LBCLO). We studied a large number of primary cutaneous LBCLs to test the validity of the classification and to identify prognostic factors for these patients. Ninety-three cases of primary cutaneous LBCL were analyzed for clinicopathologic features, expression of several markers including Bcl-2, Bcl-6, MUM-1, and FOX-P1, in situ hybridization for Epstein-Barr virus, and molecular analyses of IGH gene rearrangement and of Borrelia burgdorferi and human herpesvirus 8 DNA. Patients were classified into the following categories: FCLDT, 44 cases; LBCLLT, 40 cases; and LBCLO, 9 cases. Statistical analyses showed that the LBCLLT and FCLDT groups were clearly distinct in terms of clinicopathologic features and survival. The LBCLO group had features in between those of LBCLLT and FCLDT. Our study shows that accurate morphologic and phenotypic analyses allow us to stratify most patients into the prognostically different categories of LBCLLT and FCLDT. The definition of a third category of LBCLO requires further studies to clarify whether these cases indeed show distinct clinicopathologic features.
- Subjects :
- Adult
Aged
Aged, 80 and over
Borrelia burgdorferi metabolism
DNA Primers chemistry
Female
Forkhead Transcription Factors biosynthesis
Gene Rearrangement
Genes, Immunoglobulin Heavy Chain genetics
Herpesvirus 4, Human metabolism
Herpesvirus 8, Human metabolism
Humans
Immunohistochemistry
In Situ Hybridization
Interferon Regulatory Factors biosynthesis
Lymphoma, B-Cell classification
Lymphoma, B-Cell virology
Male
Middle Aged
Phenotype
Polymerase Chain Reaction
Prognosis
Proto-Oncogene Proteins c-bcl-2 biosynthesis
Repressor Proteins biosynthesis
Skin Neoplasms classification
Skin Neoplasms virology
Time Factors
Treatment Outcome
Lymphoma, B-Cell diagnosis
Lymphoma, B-Cell metabolism
Skin Neoplasms diagnosis
Skin Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 106
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 15947086
- Full Text :
- https://doi.org/10.1182/blood-2005-03-1175