Back to Search
Start Over
Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver disease (NAFLD) -- preliminary findings.
- Source :
-
Obesity surgery [Obes Surg] 2005 Apr; Vol. 15 (4), pp. 502-5. - Publication Year :
- 2005
-
Abstract
- Background: Pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains incompletely known, and oxidative stress is one of the mechanisms incriminated. The aim of this study was to evaluate the role of liver oxidative stress in NAFLD affecting morbidly obese patients.<br />Methods: 39 consecutive patients with BMI >40 kg/m2 submitted to Roux-en-Y gastric bypass were enrolled, and wedge liver biopsy was obtained during operation. Oxidative stress was measured by concentration of hydroperoxides (CEOOH) in liver tissue.<br />Results: Female gender was dominant (89.7%) and median age was 43.6 +/- 11.1 years. Histology showed fatty liver in 92.3%, including 43.6% with nonalcoholic steatohepatitis (NASH), 48.7% with isolated steatosis and just 7.7% with normal liver. Liver cirrhosis was present in 11.7% of those with nonalcoholic steatohepatitis. Concentration of CEOOH was increased in the liver of patients with NASH when compared to isolated steatosis and normal liver (0.26+/- 0.17, 0.20+/- 0.01 and 0.14+/- 0.00 nmol/mg protein, respectively) (P < 0.01). Liver biochemical variables were normal in 92.3% of all cases, and no difference between NASH and isolated steatosis could be demonstrated.<br />Conclusions: 1) Nonalcoholic steatosis, steatohepatitis and cirrhosis were identified in substantial numbers of morbidly obese patients; 2) Concentration of hydroperoxides was increased in steatohepatitis, consistent with a pathogenetic role for oxidative stress in this condition.
- Subjects :
- Analysis of Variance
Anastomosis, Roux-en-Y
Biopsy, Needle
Body Mass Index
Chi-Square Distribution
Cross-Sectional Studies
Fatty Liver complications
Female
Follow-Up Studies
Humans
Immunohistochemistry
Intraoperative Period
Male
Obesity, Morbid complications
Obesity, Morbid diagnosis
Probability
Prospective Studies
Risk Assessment
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome
Fatty Liver pathology
Gastric Bypass methods
Lipid Peroxidation physiology
Obesity, Morbid surgery
Oxidative Stress physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-8923
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Obesity surgery
- Publication Type :
- Academic Journal
- Accession number :
- 15946429
- Full Text :
- https://doi.org/10.1381/0960892053723493