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Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver disease (NAFLD) -- preliminary findings.

Authors :
Oliveira CP
Faintuch J
Rascovski A
Furuya CK Jr
Bastos Mdo S
Matsuda M
Della Nina BI
Yahnosi K
Abdala DS
Vezozzo DC
Alves VA
Zilberstein B
Garrido AB Jr
Halpern A
Carrilho FJ
Gama-Rodrigues JJ
Source :
Obesity surgery [Obes Surg] 2005 Apr; Vol. 15 (4), pp. 502-5.
Publication Year :
2005

Abstract

Background: Pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains incompletely known, and oxidative stress is one of the mechanisms incriminated. The aim of this study was to evaluate the role of liver oxidative stress in NAFLD affecting morbidly obese patients.<br />Methods: 39 consecutive patients with BMI >40 kg/m2 submitted to Roux-en-Y gastric bypass were enrolled, and wedge liver biopsy was obtained during operation. Oxidative stress was measured by concentration of hydroperoxides (CEOOH) in liver tissue.<br />Results: Female gender was dominant (89.7%) and median age was 43.6 +/- 11.1 years. Histology showed fatty liver in 92.3%, including 43.6% with nonalcoholic steatohepatitis (NASH), 48.7% with isolated steatosis and just 7.7% with normal liver. Liver cirrhosis was present in 11.7% of those with nonalcoholic steatohepatitis. Concentration of CEOOH was increased in the liver of patients with NASH when compared to isolated steatosis and normal liver (0.26+/- 0.17, 0.20+/- 0.01 and 0.14+/- 0.00 nmol/mg protein, respectively) (P < 0.01). Liver biochemical variables were normal in 92.3% of all cases, and no difference between NASH and isolated steatosis could be demonstrated.<br />Conclusions: 1) Nonalcoholic steatosis, steatohepatitis and cirrhosis were identified in substantial numbers of morbidly obese patients; 2) Concentration of hydroperoxides was increased in steatohepatitis, consistent with a pathogenetic role for oxidative stress in this condition.

Details

Language :
English
ISSN :
0960-8923
Volume :
15
Issue :
4
Database :
MEDLINE
Journal :
Obesity surgery
Publication Type :
Academic Journal
Accession number :
15946429
Full Text :
https://doi.org/10.1381/0960892053723493