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High-dose melphalan followed by autologous stem cell support in primary systemic AL amyloidosis with multiple organ involvement.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2005 May; Vol. 44 (5), pp. 484-9. - Publication Year :
- 2005
-
Abstract
- A patient with primary systemic AL amyloidosis achieved partial hematological response after 2 courses of VAD (vincristine, doxorubicin and dexamethasone) and subsequent high-dose melphalan followed by autologous peripheral blood stem cell transplantation despite involvement of multiple organs, including the heart. In this patient natriuretic peptides and free light chains in serum were useful as markers of cardiac involvement and therapeutic effects, respectively. When amyloidosis-related dysfunction is seen in multiple organs, this intensive chemotherapy might be a possible therapeutic option, although several modifications in the regimen and careful management are necessary.
- Subjects :
- Amyloid metabolism
Amyloidosis metabolism
Amyloidosis pathology
Biopsy, Needle
Bone Marrow pathology
Echocardiography
Follow-Up Studies
Humans
Immunoglobulin Light Chains blood
Male
Middle Aged
Myocardium metabolism
Myocardium pathology
Natriuretic Peptides blood
Submandibular Gland metabolism
Submandibular Gland pathology
Time Factors
Tongue metabolism
Tongue pathology
Transplantation, Autologous
Amyloidosis therapy
Antineoplastic Agents, Alkylating therapeutic use
Melphalan therapeutic use
Peripheral Blood Stem Cell Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0918-2918
- Volume :
- 44
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 15942100
- Full Text :
- https://doi.org/10.2169/internalmedicine.44.484