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Depression and heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study.
- Source :
-
Archives of general psychiatry [Arch Gen Psychiatry] 2005 Jun; Vol. 62 (6), pp. 661-6. - Publication Year :
- 2005
-
Abstract
- Context: Depression is associated with low heart rate variability (HRV) in patients following myocardial infarction, suggesting that alterations in the autonomic nervous system may contribute to the adverse cardiac outcomes associated with depression. Whether depression is associated with low HRV in patients with stable coronary heart disease (CHD) is not known.<br />Objective: To examine the association between major depression and 24-hour HRV in patients with stable CHD.<br />Design, Setting, and Participants: Cross-sectional study of 873 outpatients with stable CHD recruited from outpatient clinics in the San Francisco Bay Area, California.<br />Main Outcome Measures: Major depression was assessed using the Computerized National Institute of Mental Health Diagnostic Interview Schedule. Heart rate variability was measured by 24-hour ambulatory electrocardiography.<br />Results: A total of 195 participants (22%) had major depression. Overall, we observed no association between depression and HRV as measured by time domain or frequency domain variables. Mean HRV was similar in participants with and without depression (all P values >.10), and participants with depression were no more likely than those without depression to have low HRV (all P values >.10).<br />Conclusions: We found no evidence of an association between depression and HRV in 873 outpatients with stable CHD. These findings raise questions about the potential role of HRV in the association between depression and cardiovascular disease.
- Subjects :
- Aged
Ambulatory Care
Autonomic Nervous System physiopathology
Circadian Rhythm physiology
Comorbidity
Coronary Disease epidemiology
Coronary Disease physiopathology
Depressive Disorder, Major epidemiology
Depressive Disorder, Major physiopathology
Electrocardiography, Ambulatory
Female
Heart innervation
Heart Function Tests
Humans
Male
Psychiatric Status Rating Scales
Coronary Disease diagnosis
Depressive Disorder, Major diagnosis
Heart Rate physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-990X
- Volume :
- 62
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of general psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 15939843
- Full Text :
- https://doi.org/10.1001/archpsyc.62.6.661