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Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses.
- Source :
-
Nature medicine [Nat Med] 2005 Jul; Vol. 11 (7), pp. 786-90. Date of Electronic Publication: 2005 Jun 05. - Publication Year :
- 2005
-
Abstract
- Vaccines and therapies are urgently needed to address public health needs stemming from emerging pathogens and biological threat agents such as the filoviruses Ebola virus (EBOV) and Marburg virus (MARV). Here, we developed replication-competent vaccines against EBOV and MARV based on attenuated recombinant vesicular stomatitis virus vectors expressing either the EBOV glycoprotein or MARV glycoprotein. A single intramuscular injection of the EBOV or MARV vaccine elicited completely protective immune responses in nonhuman primates against lethal EBOV or MARV challenges. Notably, vaccine vector shedding was not detectable in the monkeys and none of the animals developed fever or other symptoms of illness associated with vaccination. The EBOV vaccine induced humoral and apparent cellular immune responses in all vaccinated monkeys, whereas the MARV vaccine induced a stronger humoral than cellular immune response. No evidence of EBOV or MARV replication was detected in any of the protected animals after challenge. Our data suggest that these vaccine candidates are safe and highly efficacious in a relevant animal model.
- Subjects :
- Animals
Antibody Formation
Cross Reactions
Ebola Vaccines immunology
Ebola Vaccines pharmacology
Primates
Vaccines, Attenuated genetics
Vaccines, Attenuated pharmacology
Vaccines, Combined genetics
Vaccines, Combined pharmacology
Vaccines, Synthetic genetics
Vaccines, Synthetic immunology
Vaccines, Synthetic pharmacology
Vesicular stomatitis Indiana virus genetics
Viral Vaccines genetics
Viral Vaccines pharmacology
Viremia immunology
Viremia virology
Virus Replication
Ebolavirus immunology
Marburgvirus immunology
Vaccines, Attenuated immunology
Vaccines, Combined immunology
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1078-8956
- Volume :
- 11
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature medicine
- Publication Type :
- Academic Journal
- Accession number :
- 15937495
- Full Text :
- https://doi.org/10.1038/nm1258