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Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid).
- Source :
-
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2005 Jun; Vol. 356 (1-2), pp. 35-57. Date of Electronic Publication: 2005 Mar 29. - Publication Year :
- 2005
-
Abstract
- There are many factors that contribute to hyperuricemia, including obesity, insulin resistance, alcohol consumption, diuretic use, hypertension, renal insufficiency, genetic makeup, etc. Of these, alcohol (ethanol) is the most important. Ethanol enhances adenine nucleotide degradation and increases lactic acid level in blood, leading to hyperuricemia. In beer, purines also contribute to an increase in plasma uric acid. Although rare, dehydration and ketoacidosis (due to ethanol ingestion) are associated with the ethanol-induced increase in serum uric acid levels. Ethanol also increases the plasma concentrations and urinary excretion of hypoxanthine and xanthine via the acceleration of adenine nucleotide degradation and a possible weak inhibition of xanthine dehydrogenase activity. Since many factors such as the ALDH2*1 gene and ADH2*2 gene, daily drinking habits, exercise, and dehydration enhance the increase in plasma concentration of uric acid induced by ethanol, it is important to pay attention to these factors, as well as ingested ethanol volume, type of alcoholic beverage, and the administration of anti-hyperuricemic agents, to prevent and treat ethanol-induced hyperuricemia.
- Subjects :
- Acetyl Coenzyme A biosynthesis
Alcohol Dehydrogenase genetics
Aldehyde Dehydrogenase genetics
Aldehyde Dehydrogenase, Mitochondrial
Ethanol blood
Humans
Hyperuricemia prevention & control
Hyperuricemia therapy
Lactic Acid blood
NAD metabolism
Oxidation-Reduction
Xanthine Dehydrogenase antagonists & inhibitors
Ethanol pharmacology
Hypoxanthine metabolism
Uric Acid metabolism
Xanthine metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0009-8981
- Volume :
- 356
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15936302
- Full Text :
- https://doi.org/10.1016/j.cccn.2005.01.024