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Long-term potentiation of silent synapses in substantia gelatinosa neurons.
- Source :
-
Neuroreport [Neuroreport] 2005 Jun 21; Vol. 16 (9), pp. 961-5. - Publication Year :
- 2005
-
Abstract
- In this study, we observed quantal changes in single synapse excitatory postsynaptic currents to characterize N-methyl-D-aspartate receptor-mediated silent synapses between primary afferents and spinal substantia gelatinosa neurons. The failure rate of primary afferent quantal excitatory postsynaptic currents was lower at depolarized holding potentials than at hyperpolarized potentials. This lower failure rate at depolarized potentials was due to the activation of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic currents. Pairing primary afferents with the postsynaptic depolarization induced a long-term decrease in the failure rate of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor-mediated excitatory postsynaptic currents, but did not alter the failure rate of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic currents. Our findings suggest that pairing primary afferent with postsynaptic depolarization can convert silent substantia gelatinosa synapses to active synapses and the mechanism of this synaptic plasticity is associated with postsynaptic modification.
- Subjects :
- 6-Cyano-7-nitroquinoxaline-2,3-dione pharmacology
Animals
Animals, Newborn
Chelating Agents pharmacology
Dose-Response Relationship, Radiation
Drug Interactions
Egtazic Acid pharmacology
Electric Stimulation methods
Excitatory Amino Acid Agonists pharmacology
Excitatory Amino Acid Antagonists pharmacology
Excitatory Postsynaptic Potentials drug effects
Excitatory Postsynaptic Potentials physiology
Excitatory Postsynaptic Potentials radiation effects
Glutamic Acid pharmacology
In Vitro Techniques
Long-Term Potentiation drug effects
Long-Term Potentiation radiation effects
Magnesium pharmacology
N-Methylaspartate pharmacology
Neurons cytology
Neurons drug effects
Neurons radiation effects
Rats
Rats, Sprague-Dawley
Synapses drug effects
Synapses radiation effects
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid pharmacology
Long-Term Potentiation physiology
Neurons physiology
Substantia Gelatinosa cytology
Synapses physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 15931069
- Full Text :
- https://doi.org/10.1097/00001756-200506210-00016