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Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2005 Jun; Vol. 53 (6), pp. 710-3. - Publication Year :
- 2005
-
Abstract
- From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC50, 13.8-26.1 microg/ml) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC50, 27.4 microg/ml).
Details
- Language :
- English
- ISSN :
- 0009-2363
- Volume :
- 53
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 15930790
- Full Text :
- https://doi.org/10.1248/cpb.53.710