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Antisaccade and smooth pursuit performance in positive- and negative-symptom schizotypy.
- Source :
-
Schizophrenia research [Schizophr Res] 2005 Jul 01; Vol. 76 (1), pp. 43-54. - Publication Year :
- 2005
-
Abstract
- Schizophrenic patients have well-documented abnormalities in smooth pursuit eye movements and antisaccade performance. In populations at risk for schizophrenia, smooth pursuit abnormalities are also well documented. Antisaccade deficits have been replicated in high-risk populations as well, but the findings are more variable and the reasons for the variability are not clear. Some evidence suggests that antisaccade deficits increase in high-risk populations in relation to the presence of positive symptoms. Whether antisaccade deficits increase in relation to negative symptoms in high-risk populations is relatively uninvestigated. We evaluated antisaccade and pursuit performance in "psychometric schizotypes" who had elevated scores on either the Perceptual Aberration Scale (PerAb; i.e., positive symptoms) or the Physical Anhedonia Scale (PhysAnh; i.e., negative symptoms) but not both, and in normal controls. We used the standard version of the antisaccade task, for which results in positive-symptom schizotypes have previously been reported, and investigated performance on a gap and overlap version. We replicated the finding that a significantly larger percentage of positive-symptom schizotypes than controls have elevated antisaccade error rates on the standard antisaccade task (P=0.03); the percentage of negative-symptom schizotypes with elevated antisaccade error rates did not differ from that of control subjects. Neither schizotypal group was impaired on the gap or overlap versions of the task. On the pursuit task, a higher percentage of positive- and negative-symptom schizotypes were classified as having deviant performance than control subjects (both Ps<0.04). These findings suggest that antisaccade deficits may be better at identifying high-risk subjects with positive symptoms. Pursuit deficits identified both positive- and negative-symptom schizotypes, but was better at identifying the latter.
- Subjects :
- Adolescent
Adult
Affective Symptoms physiopathology
Affective Symptoms psychology
Attention physiology
Auditory Pathways physiopathology
Brain Mapping
Diagnosis, Differential
Female
Follow-Up Studies
Frontal Lobe physiopathology
Gyrus Cinguli physiopathology
Humans
Male
Patient Admission
Perceptual Disorders physiopathology
Psychiatric Status Rating Scales
Psychometrics
Reaction Time physiology
Reference Values
Schizophrenia physiopathology
Schizotypal Personality Disorder physiopathology
Schizotypal Personality Disorder psychology
Affective Symptoms diagnosis
Perceptual Disorders diagnosis
Pursuit, Smooth physiology
Saccades physiology
Schizophrenia diagnosis
Schizophrenic Psychology
Schizotypal Personality Disorder diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0920-9964
- Volume :
- 76
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 15927797
- Full Text :
- https://doi.org/10.1016/j.schres.2004.10.005