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Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi.
- Source :
-
FEMS microbiology letters [FEMS Microbiol Lett] 2005 Jun 01; Vol. 247 (1), pp. 65-71. - Publication Year :
- 2005
-
Abstract
- Aspartate is one of the compounds that induce the differentiation process of the non-infective epimastigote stage to the infective trypomastigote stage of the protozoan parasite Trypanosoma cruzi. l-aspartate is transported by both epimastigote and trypomastigote cells at the same rate, about 3.4 pmolmin(-1) per 10(7) cells. Aspartate transport is only competed by glutamate suggesting that this transport system is specific for anionic amino acids. Aspartate uptake rates increase along the parasite growth curve, by amino acids starvation or pH decrease. The metabolic fate of the transported aspartate was predicted in silico by identification of seven putative genes coding for enzymes involved in aspartate metabolism that could be related to the differentiation process.
- Subjects :
- Adenylosuccinate Synthase genetics
Adenylosuccinate Synthase metabolism
Animals
Asparaginase genetics
Asparaginase metabolism
Aspartate Aminotransferases genetics
Aspartate Aminotransferases metabolism
Aspartate-Ammonia Ligase genetics
Aspartate-Ammonia Ligase metabolism
Biological Transport
Catalysis
Computational Biology
Kinetics
Molecular Sequence Data
Trypanosoma cruzi enzymology
Trypanosoma cruzi genetics
Aspartic Acid metabolism
Trypanosoma cruzi metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0378-1097
- Volume :
- 247
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- FEMS microbiology letters
- Publication Type :
- Academic Journal
- Accession number :
- 15927749
- Full Text :
- https://doi.org/10.1016/j.femsle.2005.04.029