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Cancer cell dissemination during curative surgery for colorectal liver metastases.
- Source :
-
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2005 Jun; Vol. 31 (5), pp. 506-11. - Publication Year :
- 2005
-
Abstract
- Aim: The amount of cancer cells disseminated during curative surgery for colorectal liver metastases (CRLM) may be responsible for recurrence. Haematogenous and intrahepatic cancer cell dissemination was evaluated, and its impact on cancer recurrence was assessed.<br />Method: Twenty patients with resectable CRLM were included in a prospective study. Twelve patients underwent curative resection for 21 metastases. Ten selected metastases in eight patients were treated with radiofrequency ablation (RFA) followed by resection at the same operative session. Cancer cell dissemination was determined before, during and after surgery using 'real time' quantitative RT-PCR assay, based on detection and quantification of CEA and CK20 mRNA transcripts.<br />Results: Circulating cancer cells were detected in 80% and intrahepatic cancer cells in 37% of the patients, though without impact on cancer recurrence. The amounts of disseminated cancer cells were significantly increased after surgery. This increase was similar in patients treated with and without RFA. RFA caused complete tumour destruction.<br />Conclusion: Curative surgery for CRLM significantly increases the amount of disseminated cancer cells. Radiofrequency ablation can completely destroy selected resectable CRLM without excessive cancer cell dissemination. Neither haematogenous nor intrahepatic cancer cell dissemination were related to cancer recurrence in this small patient series.
- Subjects :
- Aged
Biomarkers, Tumor analysis
Catheter Ablation
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Seeding
Prognosis
Proportional Hazards Models
Prospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Risk Assessment
Sensitivity and Specificity
Statistics, Nonparametric
Survival Analysis
Colorectal Neoplasms pathology
Liver Neoplasms secondary
Liver Neoplasms surgery
Neoplastic Cells, Circulating metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0748-7983
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 15922887
- Full Text :
- https://doi.org/10.1016/j.ejso.2005.01.007