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Indoleamine 2,3-dioxygenase mediates cell type-specific anti-measles virus activity of gamma interferon.
- Source :
-
Journal of virology [J Virol] 2005 Jun; Vol. 79 (12), pp. 7768-76. - Publication Year :
- 2005
-
Abstract
- Gamma interferon (IFN-gamma) has been shown to be increased in sera from patients with acute measles and after vaccination, to exhibit protective functions in brains of patients with subacute sclerosing panencephalitis, and to mediate a noncytolytic clearance of measles virus (MV) from rodent brains. In order to reveal a possible intracellular antiviral activity in the absence of antigen presentation and cytotoxic T cells, we investigated IFN-gamma-induced effects on MV replication in various tissue culture cells. While attenuated MV strains are more sensitive to IFN-alpha/beta than are wild-type strains, IFN-gamma inhibits the replication of all MV strains in epithelial, endothelial, and astroglial cells, but not in lymphoid and neuronal cell lines. The antiviral activity induced by IFN-gamma correlates with the induction of indoleamine 2,3-dioxygenase (IDO), an enzyme of the tryptophan degradation pathway known to mediate antiviral as well as antibacterial and antiparasitic effects. The IFN-gamma-induced antiviral activity can be overcome by the addition of excess amounts of l-tryptophan, which indicates a specific role of IDO in the anti-MV activity. Our data suggest that the IFN-gamma-induced enzyme IDO plays an important antiviral role in MV infections of epithelial, endothelial, and astroglial cells.
- Subjects :
- Animals
Antiviral Agents metabolism
Antiviral Agents pharmacology
Cell Line
Endothelial Cells immunology
Endothelial Cells virology
Enzyme Induction
Epithelial Cells immunology
Epithelial Cells virology
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
Interferon-gamma metabolism
Measles virus pathogenicity
Neuroglia immunology
Neuroglia virology
Tryptophan metabolism
Endothelial Cells enzymology
Epithelial Cells enzymology
Interferon-gamma pharmacology
Measles virus drug effects
Neuroglia enzymology
Tryptophan Oxygenase biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 79
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 15919929
- Full Text :
- https://doi.org/10.1128/JVI.79.12.7768-7776.2005