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Physiological monitoring of small animals during magnetic resonance imaging.
- Source :
-
Journal of neuroscience methods [J Neurosci Methods] 2005 Jun 15; Vol. 144 (2), pp. 207-13. Date of Electronic Publication: 2005 Jan 08. - Publication Year :
- 2005
-
Abstract
- Maintaining a stable physiologic state is essential when studying animal models of epilepsy with simultaneous electroencephalograph (EEG) and functional magnetic resonance imaging (fMRI) or EEG and magnetic resonance spectroscopy (MRS). To achieve and maintain such stability in rats in the MRI environment, a minimally invasive but comprehensive system was developed to monitor body temperature, heart rate, blood pressure, blood oxygen saturation and end-tidal CO2 (ETCO2) of expired gas. All physiologic parameters were successfully monitored in Sprague-Dawley rats without interfering with EEG recordings during simultaneous fMRI and MRS studies. Body temperature, heart rate, blood pressure, blood oxygen saturation, and ETCO2, were maintained between 36.5 and 37.5 degrees C, 250-450 beats/min, 136+/-17 mmHg, >90%, and 20-35 mmHg, respectively for 6-8 h under inhalational anesthesia. This set-up could be extended to study in vivo applications in other laboratory animals with only minor modifications.
- Subjects :
- Anesthetics, Inhalation pharmacology
Animals
Body Temperature drug effects
Body Temperature physiology
Brain anatomy & histology
Brain physiology
Electroencephalography
Magnetic Resonance Imaging instrumentation
Magnetic Resonance Spectroscopy instrumentation
Male
Monitoring, Physiologic instrumentation
Neurophysiology instrumentation
Rats
Stereotaxic Techniques
Magnetic Resonance Imaging methods
Magnetic Resonance Spectroscopy methods
Monitoring, Physiologic methods
Neurophysiology methods
Rats, Sprague-Dawley physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-0270
- Volume :
- 144
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuroscience methods
- Publication Type :
- Academic Journal
- Accession number :
- 15910980
- Full Text :
- https://doi.org/10.1016/j.jneumeth.2004.11.019