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Antibacterial susceptibility of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli.
- Source :
-
The Israel Medical Association journal : IMAJ [Isr Med Assoc J] 2005 May; Vol. 7 (5), pp. 298-301. - Publication Year :
- 2005
-
Abstract
- Background: The prevalence of extended-spectrum beta-lactamase-producing organisms and their antimicrobial resistance patterns may vary between geographic areas.<br />Objectives: To evaluate the prevalence and susceptibility of ESBL-producing organisms among Klebsiella pneumoniae and Escherichia coli isolated from adult and pediatric patients in two Israeli hospitals.<br />Methods: ESBL production was tested according to recommendations of the Clinical and Laboratory Standards Institute, using ceftazidime (30 microg) and a combination of ceftazidime/clavulanate (30/ 10 microg) disks with a > or =5 mm difference indicating positivity. Antibiotic susceptibilities were determined by the disk diffusion method according to CLSI standards. Minimal inhibitory concentrations were determined by the E-test.<br />Results: The prevalence of ESBL-producing organisms was significantly higher among K. pneumoniae than E. coli isolates - 32% (241/765) vs. 10% (57/547) respectively (P < 0.001), and more frequently isolated from adults than children (odds ratio 2.27 for K. pneumoniae and 12.94 for E. coli). Resistance rates for amoxicillin/ clavulanate, piperacillin-tazobactam, amikacin, and ciprofloxacin among the ESBL-producing K. pneumoniae and E. coli isolates were 95%, 82%, 49% and 77% for K. pneumoniae, and 77%, 35%, 25% and 100% for E coli. Two (0.8%) ESBL-producing and 4 (0.7%) ESBL-negative K. pneumoniae isolates showed intermediate susceptibility (MIC 6 microg/ml) to meropenem. All isolates were sensitive to ertapenem and colistin.<br />Conclusion: ESBL production among K. pneumoniae and E. coli is more prevalent in the adult population than the pediatric population and is associated with multidrug resistance.
- Subjects :
- Adult
Amikacin pharmacology
Amoxicillin pharmacology
Anti-Infective Agents pharmacology
Child
Ciprofloxacin pharmacology
Clavulanic Acid pharmacology
Enzyme Inhibitors pharmacology
Escherichia coli enzymology
Escherichia coli isolation & purification
Humans
In Vitro Techniques
Israel
Klebsiella pneumoniae enzymology
Klebsiella pneumoniae isolation & purification
Microbial Sensitivity Tests methods
Microbial Sensitivity Tests statistics & numerical data
Odds Ratio
Penicillanic Acid pharmacology
Piperacillin pharmacology
Prevalence
Tazobactam
Anti-Bacterial Agents pharmacology
Drug Resistance, Bacterial
Escherichia coli drug effects
Klebsiella pneumoniae drug effects
Penicillanic Acid analogs & derivatives
beta-Lactamases biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1565-1088
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Israel Medical Association journal : IMAJ
- Publication Type :
- Academic Journal
- Accession number :
- 15909461