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A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
- Source :
-
Nature genetics [Nat Genet] 2005 Jun; Vol. 37 (6), pp. 590-2. Date of Electronic Publication: 2005 May 22. - Publication Year :
- 2005
-
Abstract
- We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
Details
- Language :
- English
- ISSN :
- 1061-4036
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 15908952
- Full Text :
- https://doi.org/10.1038/ng1571