Voltammetric assay of Guaifenesin in pharmaceutical formulation.

Authors :: Tapsoba I
Belgaied JE
Boujlel K
Source :: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2005 Jun 01; Vol. 38 (1), pp. 162-5. Date of Electronic Publication: 2005 Jan 11.
Publication Year :: 2005
Abstract: The electrochemical oxidation of Guaifenesin in a pharmaceutical formulation containing Guaifenesin has been carried out in Britton-Robinson buffer (BRB) (0.04 mol L-1) on platinum electrode. Guaifenesin exhibits a well-defined irreversible oxidation peak at 0.924 V/ref. The influence of pH on the oxidation of Guaifenesin was studied in BRB (pH range 2-5). A method for the analysis of Guaifenesin in BRB (0.04 mol L-1, pH 2), which allows quantification over the range 20-60 microg mL-1, was proposed and successfully applied to the determination of Guaifenesin in syrup with mean recovery and relative standard deviation of 103.3% and 1.32%, respectively.