Back to Search
Start Over
Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E. coli.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2005 May 28 (20), pp. 2558-60. Date of Electronic Publication: 2005 Mar 22. - Publication Year :
- 2005
-
Abstract
- Oligosaccharidic moieties of GM(2) and GM(3) gangliosides bearing an allyl or a propargyl aglycon, are efficiently biosynthesized on the gram scale by growing metabolically engineered Escherichia coli cells in the presence of the corresponding lactoside acceptors and sialic acid.
- Subjects :
- Carbohydrate Conformation
Carbohydrate Sequence
Escherichia coli genetics
G(M2) Ganglioside chemistry
G(M3) Ganglioside chemistry
Genetic Engineering methods
Glycoconjugates chemistry
Glycosides chemistry
Molecular Sequence Data
N-Acetylneuraminic Acid chemistry
Oligosaccharides chemistry
Escherichia coli metabolism
G(M2) Ganglioside biosynthesis
G(M3) Ganglioside biosynthesis
Glycoconjugates biosynthesis
Oligosaccharides biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1359-7345
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 15900325
- Full Text :
- https://doi.org/10.1039/b500686d