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Investigation of the role of congenital cytomegalovirus infection in the etiology of enlarged vestibular aqueducts.
- Source :
-
Archives of otolaryngology--head & neck surgery [Arch Otolaryngol Head Neck Surg] 2005 May; Vol. 131 (5), pp. 388-92. - Publication Year :
- 2005
-
Abstract
- Objective: To determine whether congenital cytomegalovirus (CMV) infection is an etiologic factor in the pathogenesis of enlarged vestibular aqueducts (EVA).<br />Design: Two different cohort studies. Subjects The study population comprised 19 subjects with a history of congenital CMV infection and sensorineural hearing loss (cohort 1); 39 subjects with nonsyndromic EVA and their unaffected mothers (cohort 2); and 16 control subjects with EVA associated with Pendred syndrome and bi-allelic mutations of the SLC26A4 gene and their unaffected mothers.<br />Results: In cohort 1, we detected EVA in 0 of 19 subjects with congenital CMV infection and sensorineural hearing loss. In cohort 2, anti-CMV serologic profiles were consistent with possible congenital CMV infection in 10 (26%) of 39 subjects with nonsyndromic EVA and 6 (38%) of 16 control subjects with Pendred syndrome (P = .52). These seroprevalence rates are similar to those expected in the general population (40%).<br />Conclusion: In spite of their auditory phenotypic similarities, congenital CMV infection is not a significant factor in the etiology of EVA.
- Subjects :
- Adolescent
Audiometry
Child
Child, Preschool
Cohort Studies
Cytomegalovirus Infections genetics
Female
Hearing Loss, Sensorineural virology
Humans
Infant
Magnetic Resonance Imaging
Male
Mutation
Cytomegalovirus Infections complications
Cytomegalovirus Infections congenital
Vestibular Aqueduct virology
Subjects
Details
- Language :
- English
- ISSN :
- 0886-4470
- Volume :
- 131
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of otolaryngology--head & neck surgery
- Publication Type :
- Academic Journal
- Accession number :
- 15897416
- Full Text :
- https://doi.org/10.1001/archotol.131.5.388