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Postnatal development of parvalbumin immunoreactivity in axon terminals of basket and chandelier neurons in monkey neocortex.
- Source :
-
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 1992 May; Vol. 16 (3), pp. 329-37. - Publication Year :
- 1992
-
Abstract
- 1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to examine changes in the distribution of PV-immunoreactive (IR) chandelier and basket axon terminals during postnatal development of monkey neocortex. 3. Our results indicate a differential effect of postnatal development on PV-IR axon terminals of chandelier and basket neurons that is region-specific. 4. The differential regional, laminar and developmental pattern of PV-IR axon terminals of chandelier and basket cells may provide insight into the functional role of these classes of inhibitory neurons in primate neocortex.
- Subjects :
- Aging metabolism
Animals
Animals, Newborn physiology
Axons immunology
Cerebral Cortex cytology
Cerebral Cortex immunology
Frontal Lobe cytology
Frontal Lobe immunology
Frontal Lobe metabolism
Immunohistochemistry
Interneurons immunology
Interneurons metabolism
Macaca mulatta
Nerve Endings immunology
Neurons immunology
Parvalbumins immunology
Visual Cortex cytology
Visual Cortex immunology
Visual Cortex metabolism
Axons metabolism
Cerebral Cortex metabolism
Nerve Endings metabolism
Neurons metabolism
Parvalbumins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0278-5846
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Progress in neuro-psychopharmacology & biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 1589590
- Full Text :
- https://doi.org/10.1016/0278-5846(92)90084-r