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Postnatal development of parvalbumin immunoreactivity in axon terminals of basket and chandelier neurons in monkey neocortex.

Authors :
Akil M
Lewis DA
Source :
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 1992 May; Vol. 16 (3), pp. 329-37.
Publication Year :
1992

Abstract

1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to examine changes in the distribution of PV-immunoreactive (IR) chandelier and basket axon terminals during postnatal development of monkey neocortex. 3. Our results indicate a differential effect of postnatal development on PV-IR axon terminals of chandelier and basket neurons that is region-specific. 4. The differential regional, laminar and developmental pattern of PV-IR axon terminals of chandelier and basket cells may provide insight into the functional role of these classes of inhibitory neurons in primate neocortex.

Details

Language :
English
ISSN :
0278-5846
Volume :
16
Issue :
3
Database :
MEDLINE
Journal :
Progress in neuro-psychopharmacology & biological psychiatry
Publication Type :
Academic Journal
Accession number :
1589590
Full Text :
https://doi.org/10.1016/0278-5846(92)90084-r