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[Effects of fluoxetine and its complexes with glycyrrizhinic acid on behavior and brain monoamine levels in rats].
- Source :
-
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 2005 Mar-Apr; Vol. 55 (2), pp. 207-12. - Publication Year :
- 2005
-
Abstract
- Effects of serotonin uptake inhibitor fluoxetine (F) and it's complexes with glycyrrizhinic acid (GA) in molar proportions 1GA : 1F (FGA-1) and 4GA : 1F (FGA-4) on rat behavior in elevated plus-maze and brain monoamine concentrations were studied. Drugs (25 mg/kg) were administered per os 1 h before investigations. F-treated rats showed increased anxiety and reduced locomotor activity, whereas FGA-1 and FGA-4 had no effects on the behaviors. None of the compounds modified brain tissue serotonin content, but all of them decreased the level of its metabolite 5-hydroxyindole-3-acetic acid level in the hypothalamus, and FGA-4 also decreased it in the cortex. Noradrenaline levels were increased in the hypothalamus of rats treated with F in both combinations with GA. In the striatum, F increased dopamine and its metabolite DOPAC levels, but their ratio (an indicator of the neurotransmitter turnover) was not altered by this drug. Unlike F, FGA-1 significantly activated dopamine turnover in the striatum. The data obtained suggested that application of F in complexes with GA significantly modified the drug behavioral effects and these alterations may be related to specific effects of the pure compound and its complexes on the functions of the brain monoaminergic systems that regulate investigated behavior.
- Subjects :
- Animals
Anti-Infective Agents administration & dosage
Dopamine metabolism
Fluoxetine administration & dosage
Glycyrrhizic Acid administration & dosage
Hydroxyindoleacetic Acid metabolism
Locomotion drug effects
Male
Maze Learning drug effects
Norepinephrine metabolism
Rats
Rats, Wistar
Serotonin metabolism
Selective Serotonin Reuptake Inhibitors administration & dosage
Anti-Infective Agents pharmacology
Behavior, Animal drug effects
Biogenic Monoamines metabolism
Brain drug effects
Fluoxetine pharmacology
Glycyrrhizic Acid pharmacology
Selective Serotonin Reuptake Inhibitors pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0044-4677
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
- Publication Type :
- Academic Journal
- Accession number :
- 15895861