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The clinical potential of chemokine receptor antagonists.
- Source :
-
Pharmacology & therapeutics [Pharmacol Ther] 2005 Jul; Vol. 107 (1), pp. 44-58. - Publication Year :
- 2005
-
Abstract
- Chemokines belong to a family of chemotactic cytokines that direct the migration of immune cells towards sites of inflammation. They mediate their biological effects by binding to cell surface receptors, which belong to the G protein-coupled receptor superfamily. Since chemokines and their receptors have been implicated in the pathophysiology of a number of autoinflammatory diseases, chemokine receptor antagonists could prove to be useful therapeutics to target these diseases. Here, we review the role of chemokines in autoimmunity, concentrating mainly on the chemokine receptors CCR1 and CCR5, and discuss the potential utility of antagonists that target these 2 receptors as they progress through the clinic.
- Subjects :
- Animals
Arthritis, Rheumatoid metabolism
Arthritis, Rheumatoid physiopathology
CCR5 Receptor Antagonists
Diabetes Mellitus metabolism
Diabetes Mellitus physiopathology
Endometriosis drug therapy
Endometriosis etiology
Female
Humans
Multiple Myeloma drug therapy
Multiple Myeloma etiology
Receptors, CCR1
Receptors, Chemokine antagonists & inhibitors
Arthritis, Rheumatoid drug therapy
Autoimmune Diseases drug therapy
Autoimmune Diseases immunology
Autoimmune Diseases metabolism
Chemokines adverse effects
Chemokines metabolism
Chemokines physiology
Diabetes Mellitus drug therapy
Endometriosis physiopathology
Multiple Myeloma physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-7258
- Volume :
- 107
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 15894378
- Full Text :
- https://doi.org/10.1016/j.pharmthera.2005.01.004