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Dermatology precautions and slower titration yield low incidence of lamotrigine treatment-emergent rash.
- Source :
-
The Journal of clinical psychiatry [J Clin Psychiatry] 2005 May; Vol. 66 (5), pp. 642-5. - Publication Year :
- 2005
-
Abstract
- Objective: To assess treatment-emergent rash incidence when using dermatology precautions (limited antigen exposure) and slower titration during lamotrigine initiation.<br />Method: We assessed rash incidence in 100 patients with DSM-IV bipolar disorder instructed, for their first 3 months taking lamotrigine, to avoid other new medicines and new foods, cosmetics, conditioners, deodorants, detergents, and fabric softeners, as well as sunburn and exposure to poison ivy/oak. Lamotrigine was not started within 2 weeks of a rash, viral syndrome, or vaccination. In addition, lamotrigine was titrated more slowly than in the prescribing information. Patients were monitored for rash and clinical phenomena using the Systematic Treatment Enhancement Program for Bipolar Disorder Clinical Monitoring Form. Descriptive statistics were compiled.<br />Results: No patient had serious rash. Benign rash occurred in 5 patients (5%) and resolved uneventfully in 3 patients discontinuing and 2 patients continuing lamotrigine. Two patients with rash were found to be not adherent to dermatology precautions. Therefore, among the remaining patients, only 3/98 (3.1%) had benign rashes.<br />Conclusion: The observed rate of benign rash was lower than the 10% incidence in other clinical studies. The design of this study confounds efforts to determine the relative contributions of slower titration versus dermatology precautions to the low rate of rash. Systematic studies are needed to confirm these preliminary findings, which suggest that adhering to dermatology precautions with slower titration may yield a low incidence of rash with lamotrigine.
- Subjects :
- Adult
Ambulatory Care
Anticonvulsants therapeutic use
Cohort Studies
Drug Administration Schedule
Drug Eruptions epidemiology
Drug Eruptions etiology
Drug Monitoring
Drug Therapy, Combination
Exanthema chemically induced
Exanthema epidemiology
Female
Humans
Incidence
Lamotrigine
Male
Patient Compliance
Psychotropic Drugs therapeutic use
Self Care methods
Skin Care methods
Treatment Outcome
Triazines therapeutic use
Anticonvulsants administration & dosage
Anticonvulsants adverse effects
Bipolar Disorder drug therapy
Drug Eruptions prevention & control
Exanthema prevention & control
Triazines administration & dosage
Triazines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0160-6689
- Volume :
- 66
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of clinical psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 15889953
- Full Text :
- https://doi.org/10.4088/jcp.v66n0516