[Topical administration of hydralazine hydrochloride on the viability of randon skin flaps in rats].

Purpose: Assess the effect of hydralazine hydrochloride, for iontophoresis, on the viability of random skin flaps in rats.
Methods: Sixty Wistar rats was randonly destributed in 4 groups (n=15), these animals was submited as randon dorsal skin flaps as cranial base with measure 10 x 4 cm. The animals from group 1 was utilized as control, in group 2 was submitted to direct current o 4mA-20' immediately after the surgery and on the two subsequent days. In group 3 the stimulation eletric simulation with hydralazine hydrochloride. In group 4 iontophorese with hydralazine hydrochloride 4mA-20'. The analysis of the results was made on the seventh day post operative and interpreted with test non parametric of Kruskal-Wallis.
Results: and the necrotic area stayed fixed in: group 1=45%; group 2=39%; group 3=46% and group 4=41%, being the statistical analysis did not evidenced any significant.
Conclusion: The hydralazine hydrochloride when taken for iontophorese was not efficacious in reduce the necrotic area.