Back to Search
Start Over
Melanin-concentrating hormone enhances sucrose intake.
- Source :
-
International journal of molecular medicine [Int J Mol Med] 2005 Jun; Vol. 15 (6), pp. 1033-9. - Publication Year :
- 2005
-
Abstract
- Melanin-concentrating hormone (MCH) is known to be an important regulator for feeding and energy balance. MCH was recently reported to stimulate water intake independent of food intake. The purpose of the present study is to examine the dipsogenic response of MCH with special emphasis on sweetened beverages, the preference for which is well documented in diabetic animals. Our results showed that intracerebroventricular injection of MCH acutely increased food as well as water intake. Human (h)MCH and salmon (s)MCH increased water intake independent of food intake, which was not suppressed by angiotensin antagonists. hMCH and sMCH significantly increased both sucrose solution and food intake; on the other hand, agouti-related protein (AgRP) stimulated food but not sucrose intake when provided simultaneously. MCH-treated rats significantly increased the ingestion of sucrose and glucose solution, but not of saccharin, indicating that MCH-induced dipsogenic response is more related to caloric content than sweet taste per se. Significant correlation was observed between the sucrose intake and the mRNA expression of MCH and MCHR1 in normal rats. These results indicate that MCH may be an important regulator of sugar intake in normal as well as in obese diabetic animals.
- Subjects :
- Agouti-Related Protein
Angiotensin II pharmacology
Angiotensins antagonists & inhibitors
Animals
Circadian Rhythm
Dose-Response Relationship, Drug
Feeding Behavior drug effects
Humans
Hypothalamic Hormones genetics
Hypothalamus chemistry
Injections, Intraventricular
Male
Melanins genetics
Peptide Fragments pharmacology
Pituitary Hormones genetics
RNA, Messenger metabolism
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Salmon
Sodium Chloride metabolism
Time Factors
Drinking Behavior drug effects
Hypothalamic Hormones administration & dosage
Hypothalamic Hormones pharmacology
Melanins administration & dosage
Melanins pharmacology
Pituitary Hormones administration & dosage
Pituitary Hormones pharmacology
Sucrose metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1107-3756
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 15870910