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Differential expression of VEGF isoforms and VEGF receptors in cartilaginous tumors.
- Source :
-
Anticancer research [Anticancer Res] 2005 Mar-Apr; Vol. 25 (2A), pp. 955-7. - Publication Year :
- 2005
-
Abstract
- Vascular endothelial growth factor (VEGF), which is known to have at least five isoforms and four receptors, is integral to tumor-induced neovascularization. In order to determine whether VEGF signaling is modulated in the development of cartilaginous tumors, we analyzed osteochondrogenic tumors for the expression of VEGF isoforms and VEGF receptors using the reverse transcription-polymerase chain reaction method. Although mRNA for VEGF121, VEGF165, VEGFR-1 and NRP-2 was widely expressed, mRNA expression for VEGF189, VEGFR-2 and NRP-1 was linked to a malignant phenotype such as local invasion. These results indicated that VEGF signaling was fine-tuned by the differential expression of the VEGF isoforms and VEGF receptors.
- Subjects :
- Bone Neoplasms genetics
Bone Neoplasms metabolism
Chondroblastoma genetics
Chondroblastoma metabolism
Chondrosarcoma genetics
Chondrosarcoma metabolism
Chondrosarcoma, Mesenchymal genetics
Chondrosarcoma, Mesenchymal metabolism
Fibroma genetics
Fibroma metabolism
Humans
Neoplasms, Connective Tissue genetics
Osteochondroma genetics
Osteosarcoma genetics
Osteosarcoma metabolism
Protein Isoforms
RNA, Messenger biosynthesis
RNA, Messenger genetics
Receptors, Vascular Endothelial Growth Factor genetics
Reverse Transcriptase Polymerase Chain Reaction
Vascular Endothelial Growth Factor A genetics
Neoplasms, Connective Tissue metabolism
Osteochondroma metabolism
Receptors, Vascular Endothelial Growth Factor biosynthesis
Vascular Endothelial Growth Factor A biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 25
- Issue :
- 2A
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 15868933