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What caused the epidemic of Pneumocystis pneumonia in European premature infants in the mid-20th century?
- Source :
-
Pediatrics [Pediatrics] 2005 Jun; Vol. 115 (6), pp. e725-36. Date of Electronic Publication: 2005 May 02. - Publication Year :
- 2005
-
Abstract
- An epidemic of interstitial pneumonia principally involving premature infants occurred in Germany and nearby European countries between the 1920s and 1960s. Fatalities were due to Pneumocystis. Because the principal defenses against Pneumocystis are T cells, an acquired T-cell deficiency was postulated. A number of potential causes including malnutrition were considered. All were implausible except for a retrovirus that was benign in adults but virulent in premature infants. Furthermore, we suspect that the virus was imported into Germany from former German African colonies. Premature infants were vulnerable because of the developmental status of their T cells. Given the practices in that part of Europe at that time, the virus was most likely transmitted by contaminated blood transfusions and subsequent contamination of reusable needles and syringes used in injections. Although the epidemic ended 4 decades ago, a search for the postulated retrovirus can be conducted if tissues from affected infants are available.
- Subjects :
- Blood Transfusion instrumentation
Cameroon ethnology
Cytomegalovirus Infections complications
Cytomegalovirus Infections transmission
Disease Susceptibility
Emigration and Immigration
Equipment Contamination
Europe epidemiology
Female
Germany epidemiology
History, 20th Century
Humans
Immunity, Cellular
Immunologic Deficiency Syndromes ethnology
Immunologic Deficiency Syndromes etiology
Immunologic Deficiency Syndromes history
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases epidemiology
Infant, Premature, Diseases immunology
Lung Diseases, Interstitial epidemiology
Lung Diseases, Interstitial etiology
Lung Diseases, Interstitial immunology
Lung Diseases, Interstitial microbiology
Male
Malnutrition complications
Malnutrition epidemiology
Milk, Human cytology
Milk, Human virology
Pneumonia, Pneumocystis epidemiology
Pneumonia, Pneumocystis immunology
Pregnancy
Pregnancy Complications, Infectious epidemiology
Retroviridae Infections complications
Retroviridae Infections epidemiology
Retroviridae Infections ethnology
Retroviridae Infections history
Retroviridae Infections immunology
Retroviridae Infections transmission
Togo ethnology
Transfusion Reaction
Travel
Virulence
Warfare
Xenobiotics adverse effects
Zinc deficiency
Disease Outbreaks history
Infant, Premature, Diseases history
Lung Diseases, Interstitial history
Pneumonia, Pneumocystis history
Subjects
Details
- Language :
- English
- ISSN :
- 1098-4275
- Volume :
- 115
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 15867015
- Full Text :
- https://doi.org/10.1542/peds.2004-2157