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Exogenous interleukin-6 increases cold allodynia in rats with a mononeuropathy.

Authors :
Vissers KC
De Jongh RF
Hoffmann VL
Meert TF
Source :
Cytokine [Cytokine] 2005 May 21; Vol. 30 (4), pp. 154-9.
Publication Year :
2005

Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine, signaling intracellularly via its unique membrane-bound receptor IL-6R and gp130. In peripheral nerve injury models, IL-6 and IL-6R are increased at the injured nerve and the respective dorsal root ganglion. IL-6 is increased at the ipsilateral dorsal and ventral horn of the spinal cord. IL-6 is known to affect neuronal survival, differentiation and regeneration. It is involved in synaptic plasticity and hyperexitability and induces the synthesis or release of other substances with known neuroprotective or neuromodulatory effects. In this study, intrathecal administration of recombinant rat IL-6 to rats with a chronic constriction injury of the sciatic nerve, induced a logarithmic dose-dependent increase in cold allodynia with a threshold of 10 pg IL-6 and a maximal effect at 100 ng IL-6. Intrathecal administration of saline or denaturated IL-6 was without effect. In rats with a chronic constriction injury, systemic administered IL-6 did not induce a hyperalgesic effect, illustrating that IL-6 acts at the level of the dorsal root ganglion or the spinal cord. Intraplantar injection of 100 ng IL-6 in the operated hind paw resulted in an increased cold allodynia. This study demonstrates that the sensitivity to exogenous intrathecal or peripheral IL-6 increases in rats with a mononeuropathy.

Details

Language :
English
ISSN :
1043-4666
Volume :
30
Issue :
4
Database :
MEDLINE
Journal :
Cytokine
Publication Type :
Academic Journal
Accession number :
15863388
Full Text :
https://doi.org/10.1016/j.cyto.2005.01.008