TEL/AML1 and immunoreceptor gene rearrangements-which comes first?

Authors :: Zuna J
Krejci O
Madzo J
Fronkova E
Sramkova L
Hrusak O
Kalina T
Vaskova M
Stary J
Trka J
Source :: Leukemia research [Leuk Res] 2005 Jun; Vol. 29 (6), pp. 633-9. Date of Electronic Publication: 2005 Jan 18.
Publication Year :: 2005
Abstract: TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+ immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process.