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Mitochondria are sensors for HIV drugs.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2005 May; Vol. 26 (5), pp. 258-64. - Publication Year :
- 2005
-
Abstract
- Highly active anti-retroviral therapy (HAART) has drastically altered the course of HIV-1 infection, resulting in a major decrease in morbidity and mortality. However, adverse drug reactions and long-term toxicities associated with HAART are now a concern. A major toxicity that has been highlighted by the increased use of HAART is related to mitochondrial side-effects. At the same time, analysis of the biochemical pathways involved in programmed cell death has revealed that mitochondria are main sensors in this process. In this article, the regulation of mitochondrial damage following the use of nucleoside analogue reverse transcriptase inhibitors (NRTIs) and protease inhibitors is discussed, with a particular focus on the putative molecular mechanisms involved.
Details
- Language :
- English
- ISSN :
- 0165-6147
- Volume :
- 26
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 15860373
- Full Text :
- https://doi.org/10.1016/j.tips.2005.03.006