Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies.

Authors :: Najjar F
Gorrichon L
Baltas M
André-Barrès C
Vial H
Source :: Organic & biomolecular chemistry [Org Biomol Chem] 2005 May 07; Vol. 3 (9), pp. 1612-4. Date of Electronic Publication: 2005 Apr 04.
Publication Year :: 2005
Abstract: Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O-O bond are presented.

Subjects :: Alkylation
Animals
Antimalarials chemistry
Peroxides chemistry
Plasmodium falciparum drug effects
Antimalarials chemical synthesis
Antimalarials pharmacology
Peroxides chemical synthesis
Peroxides pharmacology

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