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Clustered DNA damage induced by heavy ion particles.
- Source :
-
Uchu Seibutsu Kagaku [Biol Sci Space] 2004 Dec; Vol. 18 (4), pp. 206-15. - Publication Year :
- 2004
-
Abstract
- Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical nature and biological consequences of clustered DNA damage and its relationship to the health effects of exposure to high LET particles in humans. The concept of clustered DNA damage emerged around 1980, but only recently has become the subject of experimental studies. In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage.
- Subjects :
- DNA Glycosylases
Electrophoresis, Gel, Pulsed-Field
Endonucleases radiation effects
Humans
Hydroxyl Radical
Linear Energy Transfer
Radiation Dosage
Radiation, Ionizing
Cosmic Radiation
DNA Damage physiology
DNA Damage radiation effects
DNA Repair physiology
DNA Repair radiation effects
Heavy Ions
Subjects
Details
- Language :
- English
- ISSN :
- 0914-9201
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Uchu Seibutsu Kagaku
- Publication Type :
- Academic Journal
- Accession number :
- 15858387
- Full Text :
- https://doi.org/10.2187/bss.18.206