Back to Search
Start Over
Endocannabinoid control of food intake and energy balance.
- Source :
-
Nature neuroscience [Nat Neurosci] 2005 May; Vol. 8 (5), pp. 585-9. - Publication Year :
- 2005
-
Abstract
- Marijuana and its major psychotropic component, Delta(9)-tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the CB(1) cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance. The endocannabinoid system controls food intake via both central and peripheral mechanisms, and it may also stimulate lipogenesis and fat accumulation. Here we discuss the multifaceted regulation of energy homeostasis by endocannabinoids, together with its applications to the treatment of eating disorders and metabolic syndromes.
- Subjects :
- Adipose Tissue drug effects
Adipose Tissue metabolism
Adipose Tissue physiopathology
Animals
Anti-Obesity Agents pharmacology
Anti-Obesity Agents therapeutic use
Appetite Regulation drug effects
Brain physiopathology
Cannabinoid Receptor Modulators agonists
Cannabinoid Receptor Modulators antagonists & inhibitors
Energy Metabolism drug effects
Humans
Neural Pathways metabolism
Neural Pathways physiopathology
Obesity drug therapy
Obesity metabolism
Obesity physiopathology
Piperidines pharmacology
Piperidines therapeutic use
Pyrazoles pharmacology
Pyrazoles therapeutic use
Receptor, Cannabinoid, CB1 agonists
Receptor, Cannabinoid, CB1 antagonists & inhibitors
Rimonabant
Appetite Regulation physiology
Brain metabolism
Cannabinoid Receptor Modulators metabolism
Endocannabinoids
Energy Metabolism physiology
Receptor, Cannabinoid, CB1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6256
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 15856067
- Full Text :
- https://doi.org/10.1038/nn1457