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Biomimetic synthesis of antimalarial naphthoquinones.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2005 May 04; Vol. 127 (17), pp. 6276-83. - Publication Year :
- 2005
-
Abstract
- The total synthesis of naphthoquinone natural products isolated from the Bignoniaceae plant family is described. Pinnatal, isopinnatal, sterekunthals A and B, pyranokunthones A and B, and anthrakunthone have been prepared along the lines of a biosynthetic proposal involving pericyclic reactions as key steps. The first case of catalysis in oxa 6pi electrocyclizations is reported.
- Subjects :
- Antimalarials chemistry
Biomimetic Materials chemistry
Crystallography, X-Ray
Cyclization
Molecular Conformation
Naphthoquinones chemistry
Naphthoquinones pharmacology
Oxidation-Reduction
Plant Extracts chemistry
Plant Extracts isolation & purification
Plant Extracts pharmacology
Antimalarials chemical synthesis
Bignoniaceae chemistry
Naphthoquinones chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0002-7863
- Volume :
- 127
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 15853334
- Full Text :
- https://doi.org/10.1021/ja050092y