Back to Search
Start Over
Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation.
- Source :
-
Transplantation proceedings [Transplant Proc] 2005 Mar; Vol. 37 (2), pp. 1326-7. - Publication Year :
- 2005
-
Abstract
- Aim: Islet transplantation is gaining recognition as a therapeutic option for selected diabetic patients. The immunosuppressive regimen based on sirolimus/low-dose tacrolimus is considered a major breakthrough that allowed considerable improvement in graft survival. A high incidence of side effects associated with such a regimen has been reported in the literature, but this immunosuppressive protocol is generally considered safe or even protective to the kidney. Herein, we analyze the impact of the sirolimus/low-dose tacrolimus-based protocol on kidney function.<br />Patients and Methods: Five islet-after-kidney and 5 islet-transplant-alone patients were enrolled and followed up. Renal function was assessed by the periodic measurement of serum creatinine and by the presence of albuminuria. Metabolic control markers and graft function were followed, as well as immunosuppressive whole blood trough levels.<br />Results: Kidney function significantly decreased in 6 of 10 patients. Neither metabolic markers nor immunosuppressive drugs levels were significantly associated with the decreased kidney function.<br />Conclusion: Although a specific etiology was not identified, subsets of patients presented a higher risk for decrease of kidney function. The presence of low creatinine clearance, albuminuria, and long-established kidney graft were associated with poorer outcomes.
- Subjects :
- Creatinine metabolism
Diabetes Mellitus, Type 1 drug therapy
Drug Therapy, Combination
Follow-Up Studies
Humans
Hypoglycemic Agents therapeutic use
Immunosuppressive Agents therapeutic use
Insulin therapeutic use
Islets of Langerhans Transplantation methods
Islets of Langerhans Transplantation physiology
Kidney Function Tests
Treatment Outcome
Diabetes Mellitus, Type 1 surgery
Islets of Langerhans Transplantation immunology
Sirolimus therapeutic use
Tacrolimus therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1345
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 15848711
- Full Text :
- https://doi.org/10.1016/j.transproceed.2004.12.040