Back to Search
Start Over
BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients.
- Source :
-
Blood [Blood] 2005 Aug 01; Vol. 106 (3), pp. 1130-2. Date of Electronic Publication: 2005 Apr 21. - Publication Year :
- 2005
-
Abstract
- We performed a case-control study to determine the association of BK plasma viremia with hemorrhagic cystitis (HC) in hematopoietic cell transplant (HCT) recipients. Thirty cases of HC (14 of which occurred after platelet engraftment with documented BK viruria [BK-HC]) were compared with matched controls. Weekly plasma samples were tested for BK virus DNA by polymerase chain reaction (PCR). BK viremia detected before or during the disease was independently associated with HC (adjusted odds ratio = 30, P < .001); BK viremia was even important before clinical symptoms of HC occurred (odds ratio = 11, P < .001). Cases of HC and BK-HC had a significantly higher peak of BK plasma viral load than controls. BK virus was detected by in situ hybridization in bladder biopsies of 2 cases with severe HC and long-lasting BK viremia. BK virus seems to play a role in the development of HC and quantitative detection of BK DNA in plasma appears to be a marker of BK virus disease in HCT recipients.
- Subjects :
- Adolescent
Adult
Case-Control Studies
Child
Cystitis etiology
DNA, Viral blood
Female
Hemorrhage
Humans
Male
Middle Aged
Odds Ratio
Polymerase Chain Reaction
Polyomavirus Infections complications
Transplantation, Homologous
Tumor Virus Infections complications
Viremia complications
BK Virus isolation & purification
Cystitis virology
Hematopoietic Stem Cell Transplantation adverse effects
Viral Load methods
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 106
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 15845896
- Full Text :
- https://doi.org/10.1182/blood-2004-12-4988