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Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population.
- Source :
-
European journal of human genetics : EJHG [Eur J Hum Genet] 2005 Jul; Vol. 13 (7), pp. 823-8. - Publication Year :
- 2005
-
Abstract
- Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is important for downregulation of T-cell activation, and CTLA-4 gene polymorphisms have been implicated as risk factors for rheumatoid arthritis (RA). Previous studies of the association between the +49 polymorphism of the CTLA-4 gene in RA have provided conflicting results. In order to determine association of the CTLA-4 gene with RA in Chinese Han population, we used denaturing gradient gel electrophoresis (DGGE) to genotype polymorphisms of four SNPs (MH30, +49, CT60 and JO31) of the CTLA-4 gene in 326 RA patients and 250 healthy controls. Furthermore, meta-analysis of all available studies relating +49 polymorphism to the risk of RA was performed to confirm the disease association. Among the SNPs examined, the genotype frequencies of CTLA-4 +49 and CT60 in RA patients differed significantly from controls (P=0.028 and 0.007). In addition, the distribution of four haplotypes constructed by these two SNPs was significantly different between patients and controls (chi(2)=10.58, d.f. =3, P=0.014). The meta-analysis also revealed that in both European and Asian populations, the CLTA-4 +49 G allele was associated with the risk of RA. These results suggested that the CTLA-4 gene might be involved in the susceptibility to RA in the Chinese Han population and both +49 and CT60 of CTLA-4 gene might be the causal variants in RA disease.
- Subjects :
- 3' Untranslated Regions
Adult
Antigens, CD
Asian People genetics
CTLA-4 Antigen
Case-Control Studies
China
Female
Genetics, Population
Haplotypes genetics
Humans
Male
Meta-Analysis as Topic
Middle Aged
Polymorphism, Single Nucleotide
Antigens, Differentiation genetics
Arthritis, Rheumatoid genetics
Genetic Predisposition to Disease
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1018-4813
- Volume :
- 13
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of human genetics : EJHG
- Publication Type :
- Academic Journal
- Accession number :
- 15841095
- Full Text :
- https://doi.org/10.1038/sj.ejhg.5201423