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Diminished in vitro production of interleukin-1 and tumor necrosis factor-alpha during acute visceral leishmaniasis and recovery after therapy.

Authors :
Ho JL
BadarĂ³ R
Schwartz A
Dinarello CA
Gelfand JA
Sobel J
Barral A
Netto MB
Carvalho EM
Reed SG
Source :
The Journal of infectious diseases [J Infect Dis] 1992 Jun; Vol. 165 (6), pp. 1094-102.
Publication Year :
1992

Abstract

Disturbance of T cell-mediated immunity has been reported in acute visceral leishmaniasis (AVL). In a study of 16 patients with AVL, defective production of interleukin-1 (IL-1) by peripheral blood mononuclear cells was demonstrated in response to leishmania antigens, heat-killed Listeria organisms, and lipopolysaccharide when compared to posttherapy values or controls. This global defect in IL-1 production was corrected after successful therapy. Twelve of 16 patients responded with a greater than or equal to 2.5-fold increase in IL-1 production that correlated with clinical cure, P less than .01. Depressed production of tumor necrosis factor (TNF) was leishmania antigen-specific and similarly recovered after therapy. In vitro TNF production during the follow-up period did not correlate with clinical status but high serum levels were associated with AVL. Since T cells are activated by processed antigens presented on class II major histocompatibility molecules and by newly synthesized IL-1, defective IL-1 production may contribute to the immunosuppression observed in AVL.

Details

Language :
English
ISSN :
0022-1899
Volume :
165
Issue :
6
Database :
MEDLINE
Journal :
The Journal of infectious diseases
Publication Type :
Academic Journal
Accession number :
1583328
Full Text :
https://doi.org/10.1093/infdis/165.6.1094