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Evaluation of hydroxypropyl-beta-cyclodextrin in the treatment of aldicarb poisoning in rats.
- Source :
-
Journal of the South African Veterinary Association [J S Afr Vet Assoc] 2004 Dec; Vol. 75 (4), pp. 182-5. - Publication Year :
- 2004
-
Abstract
- Cyclodextrins are ring-shaped oligosaccharides with a hydrophilic exterior and a hydrophobic interior. The interior cavity is capable of complexing fat-soluble molecules small enough to fit inside. Sprague-Dawley rats were used to evaluate the efficacy of hydroxypropyl-beta-cyclodextrin as treatment of aldicarb poisoning in rats. Survival times in the majority of rats dosed with aldicarb and receiving intravenous cyclodextrin were longer compared with the control rats only dosed with aldicarb per os.
- Subjects :
- 2-Hydroxypropyl-beta-cyclodextrin
Administration, Oral
Animals
Dose-Response Relationship, Drug
Injections, Intravenous veterinary
Male
Poisoning drug therapy
Poisoning veterinary
Random Allocation
Rats
Rats, Sprague-Dawley
Treatment Outcome
Aldicarb poisoning
Excipients therapeutic use
Insecticides poisoning
beta-Cyclodextrins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1019-9128
- Volume :
- 75
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of the South African Veterinary Association
- Publication Type :
- Academic Journal
- Accession number :
- 15830603
- Full Text :
- https://doi.org/10.4102/jsava.v75i4.480