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[Microparticles and cardiovascular disease].
- Source :
-
Archives des maladies du coeur et des vaisseaux [Arch Mal Coeur Vaiss] 2005 Mar; Vol. 98 (3), pp. 226-35. - Publication Year :
- 2005
-
Abstract
- Microparticles are membrane fragments liberated by activated or apoptopic cells. Thought for a long time to be cellular debris with no specific biologic function, in the vascular compartment they are a circulating reservoir of cellular effectors involved in thrombosis, inflammation, vascular remodelling and angiogenesis. High concentrations of circulating procoagulating microparticles found in many cardiovascular diseases indicate the importance of platelet, endothelial and monocytic activation and could contribute to the persistence of atherothrombotic disease. Pharmacological modulation of circulating microparticle concentrations could become a major therapeutic target in the future.
- Subjects :
- Blood Platelets metabolism
Cardiovascular Diseases prevention & control
Endothelium, Vascular metabolism
Gene Expression Regulation
Humans
Inflammation metabolism
Leukocytes metabolism
P-Selectin metabolism
Thrombosis blood
Blood Coagulation
Cardiovascular Diseases blood
Subcellular Fractions metabolism
Subjects
Details
- Language :
- French
- ISSN :
- 0003-9683
- Volume :
- 98
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives des maladies du coeur et des vaisseaux
- Publication Type :
- Academic Journal
- Accession number :
- 15816326