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Mutations in snail family genes enhance craniosynostosis of Twist1 haplo-insufficient mice: implications for Saethre-Chotzen Syndrome.
- Source :
-
Genetics [Genetics] 2005 Jun; Vol. 170 (2), pp. 971-4. Date of Electronic Publication: 2005 Mar 31. - Publication Year :
- 2005
-
Abstract
- In Drosophila, mutations in the Twist gene interact with mutations in the Snail gene. We show that the mouse Twist1 mutation interacts with Snai1 and Snai2 mutations to enhance aberrant cranial suture fusion, demonstrating that genetic interactions between genes of the Twist and Snail families have been conserved during evolution.
- Subjects :
- Animals
Cranial Sutures embryology
Craniosynostoses genetics
Drosophila
Evolution, Molecular
Genotype
Heterozygote
Humans
Mice
Mice, Transgenic
Mutation
Phenotype
Polydactyly
Snail Family Transcription Factors
Transcription Factors physiology
Acrocephalosyndactylia genetics
Nuclear Proteins genetics
Transcription Factors genetics
Twist-Related Protein 1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0016-6731
- Volume :
- 170
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 15802514
- Full Text :
- https://doi.org/10.1534/genetics.105.041277