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Behavioral responses of 129/Sv, C57BL/6J and DBA/2J mice to a non-predator aversive olfactory stimulus.
- Source :
-
Acta neurobiologiae experimentalis [Acta Neurobiol Exp (Wars)] 2005; Vol. 65 (1), pp. 29-38. - Publication Year :
- 2005
-
Abstract
- We examined the behavior of three inbred mouse strains (129/SvPasIco, C57BL/6J, and DBA/2J) exposed to an object soaked with the chemical component of the aversive scent (toluquinone odor) emitted by a myriapod species (Ommatoiulus sabulosus) in the presence of a predator. Subjects were exposed to the odor for three consecutive days. Behavioral responses to the toluquinone odor were characterized both by an approach phase of risk assessment and by a repeated series of approach-avoid episodes. Results indicate that toluquinone exposure reduced completely, and in a strain independent fashion, selected behaviors such as crouching, catching and eating object. Other responses were strain-dependent: the DBA (DBA/2J) strain displayed defensive burying at high levels, C57 (C57BL/6J) mice performed high levels of withdrawal while the 129/Sv (129/SvPasIco) strain showed also high levels of stretch attend posture. Compared to other tasks, this test is ethological, simple, cheap and is not affected by strain differences in appetitive-sensory responses, as shown by some strain-independent responses. These features make this task as a good complement to any exploration-anxiety test battery.
Details
- Language :
- English
- ISSN :
- 0065-1400
- Volume :
- 65
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta neurobiologiae experimentalis
- Publication Type :
- Academic Journal
- Accession number :
- 15794029
- Full Text :
- https://doi.org/10.55782/ane-2005-1537