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Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2005 Mar 30; Vol. 127 (12), pp. 4172-3. - Publication Year :
- 2005
-
Abstract
- The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3' end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 A), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.
Details
- Language :
- English
- ISSN :
- 0002-7863
- Volume :
- 127
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 15783190
- Full Text :
- https://doi.org/10.1021/ja043373z