Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors.

Authors :: von Haehling S
Genth-Zotz S
Bolger AP
Kalra PR
Kemp M
Adcock IM
Poole-Wilson PA
Dietz R
Anker SD
Source :: The American journal of cardiology [Am J Cardiol] 2005 Apr 01; Vol. 95 (7), pp. 885-9.
Publication Year :: 2005
Abstract: Increased levels of tumor necrosis factor-alpha (TNF-alpha) correlate with poor prognoses in chronic heart failure (CHF). This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion. The beta-blocker bisoprolol abolishes this effect.

Subjects :: Adrenergic beta-Antagonists pharmacology
Adult
Bisoprolol pharmacology
Female
Heart Failure blood
Humans
Lipopolysaccharides metabolism
Male
Receptors, Adrenergic, beta drug effects
Receptors, Adrenergic, beta physiology
Tumor Necrosis Factor-alpha analysis
Tumor Necrosis Factor-alpha biosynthesis
Cardiovascular Agents pharmacology
Heart Failure physiopathology
Isoproterenol pharmacology
Norepinephrine pharmacology
Tumor Necrosis Factor-alpha drug effects

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