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Influence of hydration status in normal subjects: fractional analysis of parameters of Tc-99m DTPA and Tc-99m MAG3 renography.
- Source :
-
Annals of nuclear medicine [Ann Nucl Med] 2005 Feb; Vol. 19 (1), pp. 1-7. - Publication Year :
- 2005
-
Abstract
- Rationale and Objectives: The purpose of this study was to evaluate the influence of hydration status upon renogram patterns and renal physiological parameters and clarify the differences between DTPA and MAG3 studies in normal volunteers.<br />Material and Methods: The study populations were 22 kidneys of 11 volunteers with no history of hypertension or renal disease with normal serum creatinine levels. They were 6 men and 5 women aged from 24 to 48 yrs (mean age: 33.4 yrs). Renal scintigraphies with both 185 MBq (5 mCi) of Tc-99m DTPA and Tc-99m MAG3 were performed after dehydration (urine specific gravity > 1.025) and adequate hydration (urine specific gravity < 1.010) in each subject at least with a 5-7-day interval. Renograms were generated from the whole kidney and cortical ROIs. We analyzed the clearance, renogram pattern, mean transit time, time to maximum activity, time from maximum activity to half activity, and residual cortical activity. Paired t-test and Wilcoxon signed rank test were used as statistical analysis methods. Statistical analysis was considered significant at p < 0.05.<br />Results: In the dehydrated state, with Tc-99m DTPA and whole kidney ROI, parameters such as time to maximum activity, time from maximum activity to half activity, residual cortical activity, and mean transit time were delayed as compared to parameters in the adequately hydrated state, but the clearance was not changed. With the cortical ROI, the changes of parameters due to dehydration were partially offset. There were insignificant differences between most parameters of Tc-99m DTPA and Tc-99m MAG3 with the whole kidney and cortical ROIs.<br />Conclusions: Dehydration may bring about a false positive curve pattern on renograms which can be prevented or minimized by using the cortical ROI. There were insignificant differences between most parameters of Tc-99m DTPA and Tc-99m MAG3.
- Subjects :
- Adult
Female
Humans
Kidney diagnostic imaging
Kidney metabolism
Male
Metabolic Clearance Rate
Middle Aged
Radiopharmaceuticals
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Body Water diagnostic imaging
Body Water metabolism
Dehydration diagnostic imaging
Dehydration metabolism
Radioisotope Renography methods
Technetium Tc 99m Mertiatide pharmacokinetics
Technetium Tc 99m Pentetate pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0914-7187
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of nuclear medicine
- Publication Type :
- Academic Journal
- Accession number :
- 15770966
- Full Text :
- https://doi.org/10.1007/BF02986328