Back to Search
Start Over
Antitumor-promoting activities of hydrolyzable tannins in mouse skin.
- Source :
-
Carcinogenesis [Carcinogenesis] 1992 Apr; Vol. 13 (4), pp. 715-8. - Publication Year :
- 1992
-
Abstract
- Ellagic acid and gallic acid and its derivatives, applied topically to female CF-1 mice 20 min before each 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment inhibit the inductions of epidermal ornithine decarboxylase activity, hydroperoxide production and DNA synthesis caused by this potent tumor promoter in relation with their abilities to inhibit the promotion of skin papillomas and carcinomas in the two-step initiation-promotion protocol. Because of its potency against TPA promotion, tannic acid, which is already known to inhibit tumor initiation, may inhibit the multistage process of carcinogenesis.
- Subjects :
- Animals
Carcinoma chemically induced
Carcinoma prevention & control
Enzyme Induction drug effects
Female
Hydrogen Peroxide metabolism
Mice
Ornithine Decarboxylase biosynthesis
Papilloma chemically induced
Papilloma prevention & control
Skin Neoplasms chemically induced
Tetradecanoylphorbol Acetate
Antineoplastic Agents pharmacology
Hydrolyzable Tannins pharmacology
Skin Neoplasms prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0143-3334
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 1576722
- Full Text :
- https://doi.org/10.1093/carcin/13.4.715