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Antitumor-promoting activities of hydrolyzable tannins in mouse skin.

Authors :
Gali HU
Perchellet EM
Klish DS
Johnson JM
Perchellet JP
Source :
Carcinogenesis [Carcinogenesis] 1992 Apr; Vol. 13 (4), pp. 715-8.
Publication Year :
1992

Abstract

Ellagic acid and gallic acid and its derivatives, applied topically to female CF-1 mice 20 min before each 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment inhibit the inductions of epidermal ornithine decarboxylase activity, hydroperoxide production and DNA synthesis caused by this potent tumor promoter in relation with their abilities to inhibit the promotion of skin papillomas and carcinomas in the two-step initiation-promotion protocol. Because of its potency against TPA promotion, tannic acid, which is already known to inhibit tumor initiation, may inhibit the multistage process of carcinogenesis.

Details

Language :
English
ISSN :
0143-3334
Volume :
13
Issue :
4
Database :
MEDLINE
Journal :
Carcinogenesis
Publication Type :
Academic Journal
Accession number :
1576722
Full Text :
https://doi.org/10.1093/carcin/13.4.715