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A novel homoisocarbacyclin analog with potent and long-lasting activity.

Authors :
Shibasaki M
Takahashi A
Aoki T
Sato H
Yamada S
Kudo M
Kogi K
Narita S
Source :
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1992 Jan; Vol. 40 (1), pp. 279-81.
Publication Year :
1992

Abstract

A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3), has been accomplished. The analog (3), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities.

Subjects

Subjects :
Animals
Epoprostenol chemical synthesis
Epoprostenol pharmacology
In Vitro Techniques
Platelet Aggregation drug effects
Platelet Aggregation Inhibitors pharmacology
Rabbits
Epoprostenol analogs & derivatives
Platelet Aggregation Inhibitors chemical synthesis

Details

Language :
English
ISSN :
0009-2363
Volume :
40
Issue :
1
Database :
MEDLINE
Journal :
Chemical & pharmaceutical bulletin
Publication Type :
Academic Journal
Accession number :
1576688
Full Text :
https://doi.org/10.1248/cpb.40.279
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