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Mitochondrial energy metabolism in heart failure: a question of balance.
- Source :
-
The Journal of clinical investigation [J Clin Invest] 2005 Mar; Vol. 115 (3), pp. 547-55. - Publication Year :
- 2005
-
Abstract
- The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.
- Subjects :
- Animals
Cardiomegaly metabolism
Cardiomegaly physiopathology
Cell Respiration physiology
Heat-Shock Proteins genetics
Heat-Shock Proteins metabolism
Humans
Myocardium cytology
Myocardium pathology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Signal Transduction physiology
Transcription Factors genetics
Transcription Factors metabolism
Transcription, Genetic
Cardiac Output, Low drug therapy
Cardiac Output, Low metabolism
Cardiac Output, Low physiopathology
Energy Metabolism
Mitochondria metabolism
Myocardium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9738
- Volume :
- 115
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 15765136
- Full Text :
- https://doi.org/10.1172/JCI24405