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Antibodies to HLA class II antigens as a risk factor for acute rejection of the allogeneic kindey.
- Source :
-
Annals of transplantation [Ann Transplant] 2004; Vol. 9 (3), pp. 44-7. - Publication Year :
- 2004
-
Abstract
- We have investigated the association between the presence of antibodies to HLA class II antigens and the development of acute and chronic rejection after kidney transplantation. Sera from seventy-one patients before, shortly (2 weeks), and in the period between 8 and 22 months after transplantation were analyzed by the standard complement-dependent cytotoxicity (CDC) test, ELISA-LATM, and LAT tests. Absence of antibodies to HLA class II antigens before and shortly after transplantation was associated with a lower incidence of rejection episodes in the first post-transplant year. Donor-specific class II antibodies could not be detected by the ELISA-LAT test and there was no statistically significant difference in serum creatinine levels between the antibody-positive and antibody-negative patient groups two years after transplantation. Our study suggests that anti-HLA class II antibodies represent a risk factor for the development of acute immunological complications during the first year after transplantation.
- Subjects :
- Acute Disease
Adult
Enzyme-Linked Immunosorbent Assay methods
Female
Graft Rejection epidemiology
Graft Survival
Humans
Incidence
Male
Middle Aged
Predictive Value of Tests
Risk Factors
Survival Analysis
Transplantation, Homologous
Antibodies blood
Graft Rejection etiology
Histocompatibility Antigens Class II immunology
Kidney Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1425-9524
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 15759547