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Lithium inhibits brown adipocyte differentiation.
- Source :
-
FEBS letters [FEBS Lett] 2005 Mar 14; Vol. 579 (7), pp. 1670-4. - Publication Year :
- 2005
-
Abstract
- Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose-dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation. Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor gamma], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1alpha, and peroxisome proliferating activated receptor alpha, are particularly sensitive to lithium treatment-dependent downregulation. Brown adipocytes appear as preferential targets of the inhibitory action of lithium on adipocyte differentiation.
- Subjects :
- Adipocytes cytology
Adipose Tissue, Brown drug effects
Animals
Biomarkers analysis
Biomarkers metabolism
Carrier Proteins genetics
Cell Differentiation drug effects
Cell Differentiation genetics
Cells, Cultured
Down-Regulation
Gene Expression drug effects
Ion Channels
Membrane Proteins genetics
Mice
Mitochondrial Proteins
Norepinephrine pharmacology
RNA, Messenger analysis
RNA, Messenger metabolism
Tretinoin pharmacology
Uncoupling Protein 1
Adipocytes drug effects
Adipose Tissue, Brown cytology
Lithium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 579
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 15757659
- Full Text :
- https://doi.org/10.1016/j.febslet.2005.02.021